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Atypical Chronic Myeloid Leukemia
Diagnosis
Clinically, aCML is characterized by anemia, thrombocytopenia, and, in 75% of cases, splenomegaly.
Pathology findings include:
- Peripheral blood leukocytosis with increased numbers of mature and immature neutrophils
- Prominent dysgranulopoiesis
- No Philadelphia chromosome or Bcr-Abl fusion gene
- Neutrophil precursors (eg, promyelocytes, myelocytes, and metamyelocytes) >10% of WBCs
- Minimal absolute basophilia with basophils <2% of WBCs
- Absolute monocytosis with monocytes typically <10% of WBCs
- Hypercellular bone marrow with granulocytic proliferation and granulocytic dysplasia
- <20% blasts in the blood or bone marrow
Reference:
National Cancer Institute. Myelodysplastic/Myeloproliferative Diseases (PDQ®): Treatment. Health Professional Version. Available at: http://www.cancer.gov/cancertopics/pdq/treatment/mds-mpd/healthprofessional/allpages. Accessed April 24, 2006.
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