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Juvenile Myelomonocytic Leukemia
Juvenile myelomonocytic leukemia (JMML) is a rare myelodysplastic/myeloproliferative disease that occurs in infants, young children, and occasionally adolescents. This Ph chromosome-negative clonal disorder is characterized by proliferation of neutrophilic and monocytic lineages.1
Epidemiology
JMML accounts for about 2% of all childhood leukemias.2 The disorder typically presents in young children (median age approximately 1 year); it occurs more commonly in boys than in girls (male to female ratio approximately 2.5:1). Children with neurofibromatosis type 1 (NF1) are at increased risk for the development of JMML.2
References:
- Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood. 2002;100:2292-2302.
- National Cancer Institute. Myelodysplastic/Myeloproliferative Diseases (PDQ®): Treatment. Health Professional Version. Available at: http://www.cancer.gov/cancertopics/pdq/treatment/mds-mpd/healthprofessional/allpages. Accessed April 24, 2006.
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